RED CELLS, IRON, AND ERYTHROPOIESIS In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2
نویسندگان
چکیده
1Department of Hematology and Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium; 2Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA; 3University of Pittsburgh School of Medicine and Pittsburgh, VA-Medical Center, Pittsburgh, PA; 4University of Texas Health Science Center, Audie L. Murphy Memorial Veterans Hospital, San Antonio, TX; 5Division of Hematology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI; 6Department of Hematology, Theagenion Cancer Center, Thessaloniki, Greece; 7US Department of Agriculture, Agricultural Research Station (USDA-ARS), Baton Rouge, LA; and 8West Los Angeles VA-University of California Los Angeles Medical Center, Los Angeles, CA
منابع مشابه
Iron regulation by hepcidin.
Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body. Physiologically, hepcidin is controlled by iron stores, inflammation, hypoxia, and erythropoiesis. The regulation of hepcidin expression by iron is a complex process that requires the coordination of multiple proteins, including hemojuvelin, bone morphogenetic protein 6 (BMP6), hereditary hemochromatosis ...
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Hepcidin is a major regulator of iron homeostasis, and its expression in liver is regulated by iron, inflammation, and erythropoietic activity with mechanisms that involve bone morphogenetic proteins (BMPs) binding their receptors and coreceptors. Here we show that exogenous heparin strongly inhibited hepcidin expression in hepatic HepG2 cells at pharmacologic concentrations, with a mechanism t...
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Anemia of chronic inflammation (ACI) is the most frequent anemia in hospitalized patients and is associated with significant morbidity. A major underlying mechanism of ACI is the retention of iron within cells of the reticuloendothelial system (RES), thus making the metal unavailable for efficient erythropoiesis. This reticuloendothelial iron sequestration is primarily mediated by excess levels...
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As a central regulator of iron metabolism, hepcidin inhibits dietary iron absorption and macrophage iron recycling. Its expression is regulated by multiple factors including iron availability and erythropoietic activity. To investigate the role of transferrin (Tf) in the regulation of hepcidin expression by these factors in vivo, we employed the hypotransferrinemic (hpx) mouse. These Tf-deficie...
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Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by -thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbbth3/ mouse. HAMP expression is activated by iron through the bone morphogenetic protein (BMP)–son of mothers against decapentaplegic signaling pathway and inhibit...
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